Endocrine Abstracts

Introduction: Ectopic thyroid glands are generally a rare entity appearing mostly in the cervical midline (90% of the cases) and even more rarely in other anatomical sites (10%).Clinical report: We present the case of an ectopic submandibular thyroid gland. A 31-year-old woman was referred to our department with a history of left submandibular swelling.A scintigraphy was performed, which showed an accumulation of activity in the ri...

Background: Cushing disease CD is a rare disorder, caused by an (ACTH) producing tumor. Transsphenoidal pituitary surgery (TSS) remains the treatment of choice for CD. Fewer information is available on the long-term outcome in the group of patients harboring ACTH-secreting adenoma. The aims of this study were to analyze our 20-year experience with surgical treatment in Cushing’s disease and to examine whether remission rate is related with size tumors.<p class="abstex...

Identifying effective strategies and underneath molecular signatures is crucial to combat certain metabolic diseases with increasing incidence such as obesity and MASLD (metabolic dysfunction-associated steatotic liver disease). The hepatic secretome plays a crucial role at controlling global energy metabolism and inflammation in MASLD. However, the interplay between diet composition and the eating architecture on the dynamic response of secretome as a tool to improve disease ...

Introduction: Adrenal Insufficiency (AI) is a heterogeneous condition comprising primary, secondary and tertiary disease. Individuals with AI suffer more frequent infections and take longer to recover. Adrenal Crises (ACs), most commonly precipitated by infections, are an acute life-threatening complication with a reported mortality of 6%. ACs are, at least in part, potentially preventable and outcomes are improved by early initiation of high-dose glucocorticoids. Currently, t...

Introduction: The SARS-CoV 2 pandemic has resulted in millions of deaths worldwide. It has been suggested that sex steroids may be involved in the prognosis of the disease.Material and methods: Male patients diagnosed with SARS-CoV-2 infection admitted to the Marqués de Valdecilla University Hospital (Spain). Testosterone, androstenedione, estradiol, DHEA and DHEAS were determined in the first 24 h of admission and severe COVID was defined as mortal...

Introduction: Diabetes Mellitus (DM) and prediabetic states (pre-DM) are well known risk factors for stroke. Admission blood glucose level and its control during hospital stay, help predicting arterial recanalization after thrombolysis and middle and long term prognosis. We analysed recurrence, mortality and nosocomial infectious complications in DM, pre-DM and patients without previous or newly diagnosed DM or pre-DM.Methods: Descriptive analysis in con...

Adipose tissue is a highly active metabolic organ which, together with its role as an energy storage depot, produces a wide variety of bioactive molecules (i.e. adipokines) with important roles in the regulation of energy metabolism and homeostasis, immunity and inflammation. Alterations in lipid metabolism and/or in adipokine production associated to the excess of adipose tissue that defines obesity or to adipose tissue deficiency, as occurs in lipodystrophy, are linked to in...

Introduction: Urine free cortisol measurements are routinely performed to evaluate hypercortisolism. Despite their analytical inaccuracy, immunoassay-based methods are frequently used. Advances in liquid chromatography high resolution mass spectrometry (LC-HRMS) facilitate the incorporation of powerful diagnostic tools into clinical laboratories with high analytical specificity that also allow simultaneous quantification of different metabolites and untargeted compound identif...

Introduction: Stroke is the second cause of death in the world and the first cause of disability. It is also the second cause of Diabetes-related death. The success of reperfusion therapies is time-dependent, with most delays being patient-related. We investigated the response to stroke in diabetic patients (DM), as their risk of stroke is increased by 1,8-6 times.Material and Methods: Consecutive patients with acute stroke or transient ischemic attack w...

ContextThyroiditis is defined as an inflammation of the thyroid gland. There are several kinds of thyroiditis, and they can be associated with either increased, decreased, or normal thyroid function (triphasic-course). Subacute granulomatous thyroiditis, also known as subacute thyroiditis (SAT), giant-cell thyroiditis, or de Quervain thyroiditis, is a self-limited thyroiditis characterized by neck pain and thyroid dysfunction. Generally, it is preceded b...